Research Interest:
My project about the benzimidazole derivatives and their anticancer activity. As we know that the benzimidazole had wide biological activities like anti-inflammatory, antibacterial, antihypertensive and others. Also it’s well known anticancer agents due to their good topoisomerase I inhibiting action and DNA binding activity. DNA-topoisomerases are enzymes present in the nuclei of cells where they catalyze the breaking and rejoining of DNA strands hence controlling the topological state of DNA. Recent studies also suggest that topoisomerases are involved in regulating template supercoiling during RNA transcription. The antitumor activity associated with agents which are topoisomerase poisons is associated with their ability to stabilize the enzyme-DNA cleavable complex. This will prevent DNA proliferation which is an important stage in the growth of the cancer cells.
